Recombinant Mouse DNMT1 Protein (His Tag)

    • Recombinant Mouse DNMT1 Protein (His Tag)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse DNMT1 Protein (His Tag)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse DNMT1 Protein (His Tag)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041380

      Synonyms:DNA (cytosine-5)-methyltransferase 1; Dnmt1; Met-1; DNA methyltransferase MmuI; DNA MTase MmuI; M.MmuI; MCMT; Dnmt; Met1; Uim

      Size:
      • 20μg
      • 100μg
      Qty:
      - +
      Price: $99

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      Overview

      Synonyms DNA (cytosine-5)-methyltransferase 1; Dnmt1; Met-1; DNA methyltransferase MmuI; DNA MTase MmuI; M.MmuI; MCMT; Dnmt; Met1; Uim
      Species Mouse
      Expression_host E.coli
      Sequence Leu1396-Pro1583
      Accession P13864-1
      Application Immunogen(E-AB-40320)
      Mol_Mass 21.46 kDa
      AP_Mol_Mass 23.76 kDa
      Tag N-His

      Properties

      Purity >80 % as determined by reducing SDS-PAGE.
      Endotoxin Not tested.
      Storage Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
      Formulation Lyophilized from sterile PBS, pH 7.4

      Background

      Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing. Promotes tumor growth.

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