Recombinant Mouse ERK2/MAPK1/MAPK2 Protein

    • Recombinant Mouse ERK2 / MAPK1 / MAPK2 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Mouse ERK2 / MAPK1 / MAPK2 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Mouse ERK2 / MAPK1 / MAPK2 Protein-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040681

      Synonyms:9030612K14Rik;AA407128;AU018647;C78273;ERK;Erk2;MAPK2;p41mapk;p42mapk;Prkm1;PRKM2

      Size:
      • 20 μg
      • 50 μg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 9030612K14Rik;AA407128;AU018647;C78273;ERK;Erk2;MAPK2;p41mapk;p42mapk;Prkm1;PRKM2
      Species Mouse
      Expression_host Baculovirus-Insect Cells
      Sequence Met1-Ser358
      Accession P63085
      Mol_Mass 41.4 kDa
      AP_Mol_Mass 37 kDa

      Properties

      Purity > 95 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice or dry ice.
      Formulation Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH 8.0
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. ERK is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that extracellular signal-regulated protein kinase 1/2 (ERK1/2) plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. Activation of ERK1/2 are implicated in the pathophysiology of spinal cord injury (SCI). ERK2 signaling is a novel target associated with the deleterious consequences of spinal injury. ERK-2, also known as Mitogen-activated protein kinase 1 (MAPK1), is a member of the protein kinase superfamily and MAP kinase subfamily. MKP-3 is a dual specificity phosphatase exclusively specific to MAPK1 for its substrate recognition and dephosphorylating activity. The activation of MAPK1 requires its phosphorylation by upstream kinases. Upon activation, MAPK1 translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. MAPK1 is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. MAPK1 acts as a transcriptional repressor which represses the expression of interferon gamma-induced genes. Transcriptional activity is independent of kinase activity. The nuclear-cytoplasmic distribution of ERK2 is regulated in response to various stimuli and changes in cell context. Furthermore, the nuclear flux of ERK2 occurs by several energy- and carrier-dependent and -independent mechanisms. ERK2 has been shown to translocate into and out of the nucleus by facilitated diffusion through the nuclear pore, interacting directly with proteins within the nuclear pore complex, as well as by karyopherin-mediated transport. ERK2 interacts with the PDE4 catalytic unit by binding to a KIM (kinase interaction motif) docking site located on an exposed beta-hairpin loop and an FQF (Phe-Gln-Phe) specificity site located on an exposed alpha-helix. These flank a site that allows phosphorylation by ERK, the functional outcome of which is orchestrated by the N-terminal UCR1/2 (upstream conserved region 1 and 2) modules.

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