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Recombinant Mouse GITR/TNFRSF18 Protein (Fc & His Tag)(Active)

  • Cat.No.:PKSM041029

  • Expression host: Human Cells

To Purchase PKSM041029

Size:
  • 10μg
  • 50μg
Price: $111
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Description

Synonyms Tumor necrosis factor receptor superfamily member 18;Glucocorticoid-induced TNFR-related protein;Tnfrsf18; AITR;CD357;GITR-D;TNFRSF18
Species Mouse
Expression_host Human Cells
Sequence Ser22-His153
Accession O35714
Application Functional ELISA
Mol_Mass 41.12 kDa
AP_Mol_Mass 60kDa
Tag C-Fc-6His
Bio_Activity Immobilized Human GITRL-His(Cat: PKSH032485) at 10μg/ml(100 μl/well) can bind Mouse GITR -Fc-His.

Properties

Purity > 90 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

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