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Recombinant Mouse IL17BR/IL17RB Protein (His Tag)

Cat:PKSM040352
Manual MSDS

Price: $ 732

Size:
100μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: Q9JIP3-1
  • Applications: ELISA
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Product Details
Synonyms Evi27;IL-17ER;IL-17Rh1;Il17br;IL17RH1
Species Mouse
Expression Host HEK293 Cells
Sequence Met1-Gly286
Accession Q9JIP3-1
Calculated Molecular Weight 31.3 kDa
Observed Molecular Weight 42 kDa
Tag C-His
Bio-activity Measured by its binding ability in a functional ELISA. Immobilized mouse IL17BR-His at 10 μg/mL (100 μl/well) can bind rat Fc-IL25.The EC50 of rat Fc-IL25 is 0.12-0.27 μg/mL.
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.