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Recombinant Mouse Interleukin-4/IL-4 Protein (His Tag)

Uniprot : P07750

Cat.No.:PKSM041094
Expression host: HEK293 Cells

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Description

Synonyms	Interleukin-4;IL-4;IL4;B-cell IgG differentiation factor;B-cell growth factor 1;B-cell stimulatory factor 1;BSF-1;IGG1 induction factor;Lymphocyte stimulatory factor 1
Species	Mouse
Expression_host	HEK293 Cells
Sequence	His21-Ser140
Accession	P07750
Mol_Mass	14.6 kDa
AP_Mol_Mass	15-19 kDa
Tag	C-His
Bio_Activity	Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells. The ED₅₀ for this effect is 0.035 ng/ml.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed man
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.

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