Recombinant Mouse MBL2/MBL/COLEC1 Protein (His Tag)

    • Mouse MBL-2 / MBL Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Mouse MBL-2 / MBL Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Mouse MBL-2 / MBL Protein (His Tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSM040947

      Synonyms:L-MBP;MBL;MBL-C;MBP-C

      Size:
      • 50 μg
      • 200 μg
      Qty:
      - +
      Price: $454

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms L-MBP;MBL;MBL-C;MBP-C
      Species Mouse
      Expression_host HEK293 Cells
      Sequence Glu19-Asp244
      Accession NP_034906.1
      Mol_Mass 26.3 kDa
      Tag N-His

      Properties

      Purity > 90 % as determined by SDS-PAGE
      Endotoxin < 1.0 EU per µg of the protein as determined by the LAL method.
      Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from sterile PBS, pH 7.4
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defence. They bind sugar structures or acetylated compounds present on microorganisms and on dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcome for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.

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