Recombinant Mouse PD-L1/B7-H1/CD274 Protein (Fc Tag)

    • Recombinant Mouse PD-L1 / B7-H1 / CD274 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Mouse PD-L1 / B7-H1 / CD274 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Mouse PD-L1 / B7-H1 / CD274 Protein (C-Fc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSM041256

      Synonyms:Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;programmed death ligand 1;B7 homolog 1;B7-H1;CD274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $62

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      Overview

      Synonyms Programmed cell death 1 ligand 1Cd274; programmed cell death 1 ligand 1;PD-L1;PDCD1 ligand 1;programmed death ligand 1;B7 homolog 1;B7-H1;CD274;B7h1;Pdcd1l1;Pdcd1lg1;Pdl1
      Species Mouse
      Expression_host Human Cells
      Sequence Phe19-Thr238
      Accession Q9EP73
      Mol_Mass 51.7 kDa
      AP_Mol_Mass 72-90 kDa
      Tag C-Fc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mouse Programmed cell death 1 ligand 1(Cd274,PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1 (PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.

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      MSDS for ELISA ISO 9001

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