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Recombinant Mouse RANKL/TNFSF11 Protein (His Tag)(Active)

  • Cat.No.:PKSM041165

  • Expression host: Human Cells

To Purchase PKSM041165

Size:
  • 10μg
  • 50μg
Price: $178
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Description

Synonyms Tumor necrosis factor ligand superfamily member 11;Tnfsf11;Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254
Species Mouse
Expression_host Human Cells
Sequence Ala73-Asp316
Accession O35235
Application Functional ELISA
Mol_Mass 28.5 kDa
AP_Mol_Mass 30-35 kDa
Tag C-6His
Bio_Activity Immobilized Human OPG-Fc(Cat: PKSH033124) at 2μg/ml(100 μl/well) can bind Mouse RANKL-His. The ED50 of Mouse RANK L-His is 2.44ug/ml .

Properties

Purity > 95 % as determined by SDS-PAGE
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.

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