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Recombinant Rat B2M/β2-MG Protein (His Tag)

Uniprot : P07151-1
  • Cat.No.:PKSR040479

  • Expression host: E.coli

To Purchase PKSR040479

Size:
  • 20µg
  • 100µg
Price: $99
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Description

Synonyms B2MG;Beta-2-Microglobulin;Beta 2 microglobin;Beta 2 microglobulin precursor;Beta chain of mhc class 1 proteins;Beta chain of MHC class I molecules;CDABP0092;Hdcma22p;IMD43
Species Rat
Expression_host E.coli
Sequence Ile21-Met119
Accession P07151-1
Mol_Mass 11.6kDa
AP_Mol_Mass 13kDa
Tag N-His

Properties

Purity >90 % as determined by reducing SDS-PAGE.
Endotoxin level No data available.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as sterile PBS,25% glycerol,PH7.4
Reconstitution Please refer to the printed manual for detailed information.

Background

β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

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