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Recombinant Rat EGFR/ErbB1 Protein (His Tag)

Cat:PKSR030363
Manual MSDS

Price: $ 732

Size:
100μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: E7CXR8
  • Applications: ELISA
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Product Details
Synonyms EGFR
Species Rat
Expression Host HEK293 Cells
Sequence Met1-Ser646
Accession E7CXR8
Calculated Molecular Weight 70.7 kDa
Observed Molecular Weight 93-110 kDa
Tag C-His
Bio-activity Measured by its ability to bind recombinant human EGF-Fc and mouse EGF-Fc in functional ELISA.
Purity > 98 % as determined by reducing SDS-PAGE.
Endotoxin Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-&alpha;, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.