Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag)

    • Recombinant Rhesus macaque HVEM / TNFRSF14 / CD270 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Rhesus macaque HVEM / TNFRSF14 / CD270 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Rhesus macaque HVEM / TNFRSF14 / CD270 Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSQ050069

      Synonyms:Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $233

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      Overview

      Synonyms Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
      Species Rhesus macaque
      Expression_host Human Cells
      Sequence Leu39-Val203
      Accession F7GSW4
      Mol_Mass 18.3 kDa
      AP_Mol_Mass 25-40 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

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      MSDS for ELISA ISO 9001

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