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Recombinant SARS-CoV Plpro/papain-like protease (His Tag)

Cat:PKSV030104
Manual MSDS

Price: $ 1105

Size:
100μg
Quantity:
  • Expression Host: E.coli
  • Accession: AAX16193.1
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For research use only. Order now, ship in 3 days

Product Details
Synonyms Plpro;papain-like protease
Species SARS
Expression Host E.coli
Sequence Glu1541-Tyr1859
Accession AAX16193.1
Calculated Molecular Weight 36.7 kDa
Tag C-His
Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 50 mM Tris, 0.1 % Tween, pH 9.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.