RSPO3 Monoclonal Antibody

  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-27337

      Synonyms:CRISTIN1,hPWTSR,hRspo3,Protein with TSP type-1 repeat,PWTSR,R-spondin 3 homolog,R-spondin-3 [Precursor],R-spondin-3,Roof plate specific spondin-3,Roof plate-specific spondin-3,RSPO3,RSPO3,Thrombospondin type I domain containing 2,Thrombospondin type-1 domain-containing protein 2,THSD2

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $226

      Host: Mouse

      Reactivity: H

      Applications: WB,IHC,IF,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms CRISTIN1,hPWTSR,hRspo3,Protein with TSP type-1 repeat,PWTSR,R-spondin 3 homolog,R-spondin-3 [Precursor],R-spondin-3,Roof plate specific spondin-3,Roof plate-specific spondin-3,RSPO3,RSPO3,Thrombospondin type I domain containing 2,Thrombospondin type-1 domain-containing protein 2,THSD2
      Swissprot Q9BXY4
      Source Mouse
      Reactivity Human
      Immunogen Fusion protein of RSPO3
      Application WB,IHC,IF,ELISA
      Recommended dilution WB 1:1000-1:10000, IHC 1:50-1:500, IF 1:50-1:500
      Clonality Monoclonal

      Properties

      Cellular localization Secreted.
      Tissue specificity Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node.
      Clone No Clone:648
      Isotype IgG2b
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 50% glycerol, PH7.3
      Background RSPO3,also named as R-spondin-3,is a 272 amino acid protein,which contains 1 TSP type-1 domain and 2 FU (furin-like) repeats. RSPO3 may be a secreted protein and belongs to the R-spondin family. RSPO3 is expressed at higher level in placenta,small intestine,fetal thymus and lymph node. RSPO3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. The four R-spondins (RSPO1–4) and three related leucinerich repeat-containing G-protein coupled receptors,LGR4,LGR5,and LGR6 (LGR4–6),constitute a ligand–receptor system that plays critical roles in development,stem cell survival,and oncogenesis. Ectopic expression of RSPO2/3in mouse mammary epithelial cells led to an increase in invasiveness in vitro and in tumor formation and metastasis in vivo.

      Images

      Western Blot analysis of Human skeletal muscle tissue using RSPO3 Monoclonal Antibody at dilution of 1:2000

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