SIRT2 Polyclonal Antibody

Uniprot : Q8IXJ6
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14345

      Synonyms:FLJ35621,FLJ37491,NAD dependent deacetylase sirtuin 2,NAD-dependent deacetylase sirtuin-2,NAD-dependent protein deacetylase sirtuin-2,Regulatory protein SIR2 homolog 2,Silencing information regulator 2 like,Silent information regulator 2,SIR2,SIR2 like protein 2,Sir2 related protein type 2,SIR2,S. cerevisiae,homolog-loke 2,SIR2-like protein 2,SIR2L,SIR2L2,SIRT2,SIRT2,Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae),Sirtuin 2,Sirtuin type 2

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms FLJ35621,FLJ37491,NAD dependent deacetylase sirtuin 2,NAD-dependent deacetylase sirtuin-2,NAD-dependent protein deacetylase sirtuin-2,Regulatory protein SIR2 homolog 2,Silencing information regulator 2 like,Silent information regulator 2,SIR2,SIR2 like protein 2,Sir2 related protein type 2,SIR2,S. cerevisiae,homolog-loke 2,SIR2-like protein 2,SIR2L,SIR2L2,SIRT2,SIRT2,Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae),Sirtuin 2,Sirtuin type 2
      Swissprot Q8IXJ6
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human SIRT2
      Application WB(Detection kit: E-IR-R304),ELISA
      Recommended dilution WB 1:200-1:1000
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton. Colocalizes with microtubules.
      Tissue specificity Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

      Images

      Western Blot analysis of Mouse heart tissue using SIRT2 Polyclonal Antibody at dilution of 1:350

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