SPAG5 Polyclonal Antibody

Uniprot : Q96R06
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14365

      Synonyms:Astrin,Deepest,hMAP 126,hMAP126,MAP 126,MAP126,Mitotic spindle associated protein,Mitotic spindle associated protein p126,Mitotic spindle coiled coil related protein,Mitotic spindle-associated protein p126,SPAG 5,SPAG5,SPAG5,Sperm associated antigen 5,Sperm tail protein Spag 5,Sperm tail protein Spag5,Sperm-associated antigen 5

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Astrin,Deepest,hMAP 126,hMAP126,MAP 126,MAP126,Mitotic spindle associated protein,Mitotic spindle associated protein p126,Mitotic spindle coiled coil related protein,Mitotic spindle-associated protein p126,SPAG 5,SPAG5,SPAG5,Sperm associated antigen 5,Sperm tail protein Spag 5,Sperm tail protein Spag5,Sperm-associated antigen 5
      Swissprot Q96R06
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human SPAG5
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Cytoplasm>cytoskeleton>spindle. Cytoplasm>cytoskeleton>spindle pole. Chromosome>centromere>kinetochore. In a punctate pattern in interphase cells. During mitosis, detected at spindle poles during prophase, throughout the spindle in metaphase and anaphase, and at midzone microtubules in anaphase and telophase. Detected on kinetochores of chromosomes that have congressed. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.
      Tissue specificity Highly expressed in testis. Detected at low levels in placenta, liver, pancreas, thymus and colon.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene. This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments.

      Images

      Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using SPAG5 Polyclonal Antibody at dilution 1:35

      Immunohistochemistry of paraffin-embedded Human lung cancer tissue using SPAG5 Polyclonal Antibody at dilution 1:35

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