TGF β Receptor I Monoclonal Antibody

  • TGF β Receptor I Monoclonal Antibody-Elabscience
  • Pathological antibodies-Elabscience
  • Pathological antibodies-Elabscience
    • TGF β Receptor I Monoclonal Antibody-Elabscience
    • Pathological antibodies-Elabscience
    • Pathological antibodies-Elabscience
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    • TGF β Receptor I Monoclonal Antibody-Elabscience
    • Pathological antibodies-Elabscience
    • Pathological antibodies-Elabscience
    • TGF β Receptor I Monoclonal Antibody-Elabscience
    • Pathological antibodies-Elabscience
    • Pathological antibodies-Elabscience
      Catalog number:E-PA-3401

      Synonyms:TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth

      Size:
      • 0.1mL
      • 0.2mL
      Qty:
      - +
      Price: Inquire

      Reactivity: Human

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Background

      Background TGFBR1 (Transforming Growth Factor Beta Receptor 1) is a Protein Coding gene. Diseases associated with TGFBR1 include Multiple Self-Healing Squamous Epithelioma, Susceptiblity To and Loeys-Dietz Syndrome 1. Among its related pathways are PEDF Induced Signaling and SMAD2/3 MH2 Domain Mutants in Cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ACVR1B.

      Overview

      Synonyms TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth
      Swissprot P36897
      Source Mouse
      Reactivity Human
      Immunogen Full length protein from eukaryotic expression system.
      Application IHC-p
      Recommended dilution IHC 1:500
      Concentration 1mg/mL
      Clonality Monoclonal

      Properties

      Positive_control Malignant tumour
      Cellular localization Cytoplasm
      Specificity This antibody detects endogenous levels of TGF β Receptor I
      Clone No. Clone:2F2
      Isotype IgG
      Purify Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃, Avoid freeze / thaw cycles
      Storage buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Function Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell su

      Images

      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon caner tissue labeling TGF β Receptor I Monoclonal Antibody with E-PA-3232 at dilution of 1:500. Heat induced epitope retrieval was performed by boiling the tissue sections in citrate buffer(PH6.0)for 20 minutes. Incubation with the primary antibody was performed for overnight at 4℃ followed by keeping at room temperature for 15mins. HRP conjugated Anti-Mouse secondary antibody was applied for 30 minutes at room temperature followed by DAB as chromogen, then counterstain with haematoxylin.
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