TGF β Receptor II Monoclonal Antibody

  • Pathological antibodies-Elabscience
    • Pathological antibodies-Elabscience
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    • Pathological antibodies-Elabscience
    • Pathological antibodies-Elabscience
      Catalog number:E-PA-3402

      Synonyms:TGF-beta receptor type-2 ,TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TGF-beta receptor type II,TbetaR-II

      Size:
      • 0.1mL
      • 0.2mL
      Qty:
      - +
      Price: Inquire

      Reactivity: Human

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Background

      Background TGFBR2 (Transforming Growth Factor Beta Receptor 2) is a Protein Coding gene. Diseases associated with TGFBR2 include Loeys-Dietz Syndrome 2 and Esophageal Cancer. Among its related pathways are SMAD2/3 MH2 Domain Mutants in Cancer and Extracellular vesicle-mediated signaling in recipient cells. GO annotations related to this gene includetransferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ACVR2B.

      Overview

      Synonyms TGF-beta receptor type-2 ,TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TGF-beta receptor type II,TbetaR-II
      Swissprot P37173
      Source Mouse
      Reactivity Human
      Immunogen Full length protein from eukaryotic expression system.
      Application IHC-p
      Recommended dilution IHC 1:500
      Concentration 1mg/mL
      Clonality Monoclonal

      Properties

      Positive_control Malignant tumour
      Cellular localization Cytoplasm
      Specificity This antibody detects endogenous levels of TGF β Receptor II
      Clone No. Clone:AS1A37
      Isotype IgG
      Purify Antigen affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃, Avoid freeze / thaw cycles
      Storage buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      Function Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

      Images

      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human colon caner tissue labeling TGF β Receptor II Monoclonal Antibody with E-PA-3233 at dilution of 1:500. Heat induced epitope retrieval was performed by boiling the tissue sections in citrate buffer(PH6.0)for 20 minutes. Incubation with the primary antibody was performed for overnight at 4℃ followed by keeping at room temperature for 15mins. HRP conjugated Anti-Mouse secondary antibody was applied for 30 minutes at room temperature followed by DAB as chromogen, then counterstain with haematoxylin.
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