Synonyms:Tryptase delta (EC 188.8.131.52) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3)
|Synonyms||Tryptase delta (EC 184.108.40.206) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3)|
|Immunogen||Synthesized peptide derived from Tryptase-3|
|Recommended dilution||WB 1:500-2000, ELISA 1:10000-20000|
|Cellular localization||Extracellular region or secreted,extracellular region|
|Tissue specificity||Expressed in colon, lung, heart and synovial tissue. May be specific to mast cells.|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.|
|Background||TPSD1 (Tryptase Delta 1) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is TPSAB1.Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.|
Western Blot analysis of HepG2 cells using TPSD1 Polyclonal Antibody at dilution of 1:800.
Immunohistochemistry of paraffin-embedded Human tonsil tissue using TPSD1 Polyclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human skin tissue using TPSD1 Polyclonal Antibody at dilution of 1:200.