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For research use only.

Verified Samples Verified Samples in IHC: Human lung, Human duodenal cancer, Mouse lung, Rat lung
Dilution IHC 1:200-1:500
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Recombinant Human Deleted in malignant brain tumors 1 protein
Abbre DMBT1
Synonyms CRP,   Crpd,   DBMT1,   DMBT1,   DMBT1 prototype precursor,   Deleted in malignant brain tumors 1 protein,   Ebnerin,   FLJ61058,   GP340,   Glycoprotein 300,   Glycoprotein 340,   Gp340 variant protein,   Hensin,   MGC164738,   Muclin,   Pancrin,   SAG,   Salivary ag,   p80,  Apactin
Swissprot
Cellular Localization Secreted
Concentration 0.71 mg/mL
Buffer PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method Antigen Affinity Purification
Research Areas Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.
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Unconjugated

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