Recombinant CD25 Monoclonal Antibody (AN301472L)
For research use only.
| Verified Samples |
Verified Samples in IF: Jurkat, K562 Verified Samples in FCM: Jurkat |
| Dilution | IF 1:50, FCM 1:50-1:100 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, |
| Applications | IF, FCM |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human CD25 fragment |
| Abbre | CD25 |
| Synonyms | IMD, IDDM, IL2RA, CD25, IDDM10, IL2R, IMD41, TCGFR, p55, IL-2 receptor subunit alpha, IL-2R subunit alpha, IL2-RA, IL-2-RA, IL-2Rα, Interleukin-2 receptor subunit alpha, TAC antigen, Tac, p55, IL-2R&, alpha, alpha chain, CD25 antigen, IL 2 receptor alpha subunit, IL2 RA, Interleukin 2 receptor, Interleukin 2 receptor alpha, Interleukin 2 receptor alpha chain, t-cell growth factor receptor |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Immunology |
| Clone No. | A167 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. |
Other Clones
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Other Formats
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Unconjugated
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