Cancer is a group of diseases characterized by autonomous, uncontrolled cell growth and proliferation and has become one of the leading causes of morbidity and mortality worldwide. Cancer cells are allowed to grow and divide, invade or spread to other parts of the body out of control by changes to genes. Many common types of cancer including lung cancer, colon cancer, rectum cancer, stomach cancer, liver cancer do a great harm to human health. Systematically studying on these malignant diseases will help us find therapeutic strategies to inhibit cancer progression.
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Akt signaling pathway is closely related to the occurrence and development of many diseases, such as malignant tumor, diabetes, rheumatoid arthritis and so on.
Matrix metalloproteinases (MMP) are a class of proteolytic enzymes dependent on zinc ion, which play an important role in degradation, organization and reconstruction of extracellular matrix (ECM) and regulation of intracellular soluble factors.