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Will polyformaldehyde fixation damage cell membranes?

Source: Elabscience®Published: Aug 14,2024

Polyformaldehyde (PFA) is a commonly used tissue fixative, typically used to immobilize proteins and cellular structures in biological samples. Although PFA can help maintain cell structure and protein morphology, PFA fixation may cause damage to the cell membrane due to its permeability, which can fix proteins inside and outside the cell. Additionally, the permeability of different cells may not be consistent. The appropriate fixative should be selected based on which aspect of research will be used for the cell membrane.