ELISA Research
Why is the amino acid sequence of human angiotensin II different between NCBI and Uniprot
Source: Elabscience®Published: Mar 04,2024
angiotensin II [Homo sapiens]GenBank in NCBI: CAA77513.1 shows that the protein with fixed number "P30556" of Uniprot is "Type-1 angiotensin II receptor", which is a Type 1 receptor of angiotensin II and not the same protein as angiotensin II.
The Uniprot database is composed of Swiss-Prot, TrEMBL and PIR-PSD sub-databases. The data are mainly from the whole gene protein sequences obtained after genome sequencing of each species, and contain a lot of protein and its function information from the literature. NCBI(US National Center for Biotechnology Information) data resources from several major DNA databases around the world, including the Japanese DNA database DDBJ, the European Molecular Biology Laboratory database EMBL and several other well-known scientific research institutions, the two sources of information may be inconsistent, sometimes in terms of the name is not strictly audited, there may be a certain discrepancy.