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Does the sC5b-9(sC5b-9) kit detect activated or unactivated MAC, because MAC is present on the cell, so where is the main source of dissolved MAC? Is this result representative of MAC formation on cells?

Source: Elabscience®Published: Mar 08,2024

The sC5b-9 kit detects the total, both active and inactive forms. MAC is present on cells, but when the multifunctional glycoprotein S protein (vitronectin) binds to the liquid phase of C5b9, it forms a complex that cannot attach to cells, called SC5b9. SC5b-9 is a membrane-attacking complex present in plasma. At abnormally elevated concentrations, SC5B-9 exhibits cytotoxicity, interacts with cytoskeletal components or membrane proteins to produce non-lethal effects on cells, and plays an important role in the pathological process of certain diseases. This kit measures the concentration of sC5b-9, which is generally used to study disease models related to sC5b-9 indicators, and can show changes in concentration between groups, but cannot represent the formation process of MAC on cells.