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100Tests $ 228.00
20Tests $ 75.00
100Tests×2 $ 342.00
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For research use only.

Background IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively.
Alternate Names IL17,  CTLA-8,  CTLA8,  IL 17A
Swissprot
Clone No
Host Mouse
Reactivity Human
Isotype Mouse IgG1, κ
Isotype Control
Application
ICFCM
Cellular Localization
Secreted
Form Liquid
Conjugation
FITC
Conjugation information FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter).
Spectrum
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date 12 months
Shipping Ice bag
Cat.No. Product Name Sizes
E-CK-A091 Cell Stimulation and Protein Transport Inhibitor Kit 500Assays , 200Assays , 100Assays , 50Assays
E-CK-A105 10×ACK Lysis Buffer 500mL , 200mL , 100mL
E-CK-A107 Cell Staining Buffer 500mL , 200mL , 100mL
E-CK-A109 Intracellular Fixation/Permeabilization Buffer Kit 500Assays , 100Assays , 50Assays
Other Clones

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Other Formats

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APC

Biotin

Elab Fluor®647

Elab Fluor®Violet 450

FITC

PE

PE/Cyanine 7

Unconjugated

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