FITC Anti-Human IL-17A Antibody[BL168] (E-AB-F1173C)
For research use only.
Background | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
Alternate Names | IL17, CTLA-8, CTLA8, IL 17A |
Swissprot | |
Clone No | |
Host | Mouse |
Reactivity | Human |
Isotype | Mouse IgG1, κ |
Isotype Control | |
Application |
ICFCM
|
Cellular Localization |
Secreted
|
Form | Liquid |
Conjugation | FITC |
Conjugation information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration date | 12 months |
Shipping | Ice bag |
Other Clones
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Other Formats
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APC
Biotin
Elab Fluor®647
Elab Fluor®Violet 450
FITC
PE
PE/Cyanine 7
Unconjugated
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