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Akt, also known as protein kinase B (PKB), is a serine/threonine protein kinase with a molecular weight of approximately 60 kDa. AS an important crossover point of many signaling pathways, Akt can regulate cell survival signals activated by cytokines, growth factors and Oncogene Ras, which is very common in eukaryotic regulatory networks…Read More..
JAK-STAT signaling pathway is a signal transduction pathway stimulated by cytokines. Compared with other signaling pathways, this signal transduction pathway is relatively simple. It consists of three components, tyrosine kinase-related receptors, tyrosine kinase JAK and transcription factor STAT. Many cytokines and growth factors transmit signals through JAK-STAT signaling pathways...Read More..
ERK is a member of the Mitogen-activated protein kinase (MAPK) family. Its signal transduction pathway is the core of signal networks involved in the regulation of cell growth, development, and division. The MAPK-ERK pathway is activated by various receptors involved in growth and differentiation, including receptor tyrosine kinases (RTKs), integrins, and ion channels...Read More..
P53 has been found most associated with human tumors of all genes. P53 mutations occur in the vast majority of tumor cells and in more than 50% of all malignant tumors. The protein encoded by this gene is a transcription factor that controls the initiation of the cell cycle. Many signals about cellular health are sent to P53 protein and it determines whether the cell enter a division cycle...Read More..
Apoptosis is also known as programmed cell death. It is an ordered natural or physiological process of cell death that occurs under the control of a series of endogenous genes to maintain the internal environment. Apoptosis is a death process that the body actively seeks for in order to better adapt to the living environment. It involves the activation, expression and regulation of a series of genes…Read More..
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