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100μg $ 90.00
25μg $ 55.00
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For research use only.

Background The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
Alternate Names CD162,  P-selectin glycoprotein ligand 1,  PSGL-1,  Selectin P ligand,  Selplg
Swissprot
Clone No
Host Rat
Reactivity Mouse
Isotype Rat IgG1, κ
Isotype Control
Application
FCM
Cellular Localization
Membrane
Form Liquid
Conjugation
Biotin
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage This product can be stored at 2-8°C for 12 months. Do not freeze.
Expiration date 12 months
Shipping Ice bag
Cat.No. Product Name Sizes
E-CK-A105 10×ACK Lysis Buffer 500mL , 200mL , 100mL
E-CK-A107 Cell Staining Buffer 500mL , 200mL , 100mL
Other Clones

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Other Formats

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APC

Biotin

Elab Fluor®488

Elab Fluor®647

Elab Fluor®700

Elab Fluor®Violet 450

FITC

None (AF/LE)

PE

PE/Cyanine 5

PE/Cyanine 5.5

PE/Cyanine 7

PE/Elab Fluor®594

PerCP/Cyanine 5.5

Unconjugated

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