For research use only.
| Synonyms | CD358, DR6, Death Receptor 6, TNFRSF21, Tumor Necrosis Factor Receptor Superfamily Member 21 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Leu 350 |
| Accession | NP_055267.1 |
| Calculated Molecular Weight | 60.3 kDa |
| Observed Molecular Weight | 95-100 kDa |
| Tag | C-hFc |
| Bio-activity | Immobilized recombinant human DR6-Fc at 10 μg/mL (100 μl/well) can bind biotinylated human APP-Fc with a linear range of 0.03-0.25 μg/mL. |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | TNFRSF21 (death receptor-6; DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain; and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production; suggested that DR6 serves as an important regulatory molecule in T-helper cell activation; and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs; heart; brain and pancreas. Some tumor cells overexpress DR6; typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion; which is subject to future investigations. |
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