For research use only.
| Verified Samples |
Verified Samples in IHC: Human brain |
| Dilution | IHC 1:50-1:200 |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human ABL1 |
| Synonyms | ABL, ABL proto oncogene 1 non receptor tyrosine kinase, ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine protein kinase 1, Abl 1, bcr/abl, bcr/c abl oncogene protein, c ABL, c abl oncogene , c abl oncogene 1 non receptor tyrosine kinase |
| Swissprot | |
| Cellular Localization | Cytoplasm>cytoskeleton. Nucleus. Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane. The myristoylated c-ABL protein is reported to be nuclear. |
| Concentration | 0.5 mg/mL |
| Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response.Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene.The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia.The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
Other Clones
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