Cell Apoptosis
Apoptosis: A Key Process in Programmed Cell Death, a form of programmed cell death (PCD), is a genetically controlled and orderla form of programmed cell death (PCD), is a genetically regulated process essential for cell growth, development, and renewal. Key events include phosphatidylserine (PS) externalization, mitochondrial membrane potential (ΔΨm) changes, caspase activation, and DNA fragmentation. This orderly self-destruction occurs under physiological or pathological conditions, helping organisms adapt to their environment. Proper apoptosis is critical for maintaining cellular balance, while dysregulation can lead to diseases such as cancer and neurodegenerative disorders.
Elabscience® Apoptosis Detection Kits
Apoptosis detection is a critical tool for analyzing cell fate and disease mechanisms. Elabscience® offers comprehensive apoptosis detection kits covering multiple key apoptotic pathways, enabling precise identification of essential steps in the cell death process.
• 15 fluorochromes paired with 3 nuclear dyes
• Complete the experiment in just 15 minutes
• Distinct cell populations, effective even with high cell density
• Free of dimethyl arsenic, safe and non-toxic
• Wide variety, compatible with all detection equipment
• High sensitivity, comparable to leading international brands
• Comprehensive panel, detects 8 types of Caspases
• Wide variety, available in both fluorescence and spectrophotometry methods
• Simple operation, delivering accurate experimental results
• Early apoptosis detection
• Simple experimental procedure
• Mitochondrial localization and function assessment
Apoptopic process events
1. The cell membrane loses its symmetry
2. Activation of apoptosis-related proteins such as Bcl-2
3. Caspase Activation
4. Mitochondrial membrane potential collapses, cytometers C is released
5. Increase in sub-G1 cell population
6. Cell nuclear shrinkage
7. DNA fragmentation
8. Cell membrane budding to form apoptotic bodies
Point of no return
Schematic Diagram of Apoptosis Process Features
Annexin V detection（Early apoptosis）
Cell membrane PS eversion
Caspase detection（Early apoptosis）
Caspase activity assay
JC-1（Early apoptosis）
Decreased mitochondrial membrane potential
TUNEL（Late apoptosis）
DNA break
Features of Elabscience® Apoptosis Detection Kits
Comprehensive Panel: Offers a range of apoptosis detection kits, covering detection from early to late stages of apoptosis.
High Compatibility: Supports multiple detection platforms, including flow cytometers, fluorescence microscopes, microplate readers and spectrophotometers.
Easy to Use: Complete reagents included, with a simple and straightforward experimental procedure.
Excellent Performance: Product quality comparable to leading international brands, ensuring reliable and worry-free detection.
Elabscience® Apoptosis Detection Kits - Experimental Results Display
Publications
