For research use only.
| Background | CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. |
| Alternate Names | CD103, Integrin alpha M290, Integrin alpha-E, Itgae |
| Swissprot | |
| Clone No | |
| Host | Rat |
| Reactivity | Mouse |
| Isotype | Rat IgG2a, κ |
| Application |
FCM;Block
|
| Conjugation | Unconjugated |
| Storage Buffer | 0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
| Storage | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Expiration date | 12 months |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
Other Clones
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Other Formats
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APC
Biotin
Elab Fluor®488
Elab Fluor®647
FITC
PE
PE/Cyanine 5
PE/Cyanine 5.5
PE/Cyanine 7
Unconjugated
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