AK2 Polyclonal Antibody

Uniprot : P54819
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14703

      Synonyms:Adenylate kinase 2,adenylate kinase 2, mitochondrial,Adenylate kinase isoenzyme 2,ADK2,AK 2,ak2,ATP AMP transphosphorylase,ATP-AMP transphosphorylase 2,EC 2.7.4.3,KAD2,mitochondrial

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Adenylate kinase 2,adenylate kinase 2, mitochondrial,Adenylate kinase isoenzyme 2,ADK2,AK 2,ak2,ATP AMP transphosphorylase,ATP-AMP transphosphorylase 2,EC 2.7.4.3,KAD2,mitochondrial
      Swissprot P54819
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human AK2
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:50-1:200
      Concentration 0.2 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Mitochondrion intermembrane space.
      Tissue specificity Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.

      Images

      Western Blot analysis of Human placenta tissue and A549 cell, Mouse brain tissue and hepG2 cell, Raji cell and Human fetal liver tissue, hela cell using AK2 Polyclonal Antibody at dilution of 1:250

      Immunohistochemistry of paraffin-embedded Human thyroid cancer using AK2 Polyclonal Antibody at dilution of 1:30

      Immunohistochemistry of paraffin-embedded Human breast cancer using AK2 Polyclonal Antibody at dilution of 1:30

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