Synonyms:2 methylacyl CoA racemase,2-methylacyl-CoA racemase,Alpha methylacyl CoA racemase,Alpha-methylacyl-CoA racemase,Amacr,AMACR,AMACRD,CBAS4,EC 184.108.40.206,Macr1,RACE,RM
|Synonyms||2 methylacyl CoA racemase,2-methylacyl-CoA racemase,Alpha methylacyl CoA racemase,Alpha-methylacyl-CoA racemase,Amacr,AMACR,AMACRD,CBAS4,EC 220.127.116.11,Macr1,RACE,RM|
|Application||WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R213),IF|
|Recommended dilution||WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:300|
|Cellular localization||Peroxisome. Mitochondrion.|
|Purification||Protein A purification|
|Storage instructions||Store at -20℃. Avoid freeze / thaw cycles.|
|Storage buffer||PBS with 0.02% sodium azide, 50% glycerol, pH7.4|
|Background||This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene.|
Western Blot analysis of 1) HepG2, 2) Mouse kidney using AMACR Monoclonal Antibody at dilution of 1:1000.
Immunohistochemistry of paraffin-embedded Human stomach tissue using AMACR Monoclonal Antibody at dilution of 1:200.
Immunofluorescence analysis of Mouse kidney tissue using AMACR Monoclonal Antibody at dilution of 1:200.