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Elab Fluor® 647 Anti-Human CD74 Antibody[LN2]

Uniprot : P04233
  • Cat.No.:E-AB-F1072M

  • Applications: FCM
  • Isotype: Mouse IgG1, κ
  • Host: Mouse

To Purchase E-AB-F1072M

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  • 20Tests
  • 100Tests
  • 100Tests×2
Price: $115
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Antigen Details

Alternate Names HLA class II histocompatibility antigen gamma chain,CD74,Ia antigen-associated invariant chain,Ii,p33,DHLAG
Swissprot P04233
References
1. Moldenhauer G, et al. 1999. Immunology 96:473.
2. Shi X, et al. 2006. Immunity 25:595.
3. Beswick EJ, et al. 2006. Infect. Immun. 74:1148.
4. Zola H,et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication.

Product Details

Form Liquid
Clone No. LN2(See Other Available Formats)
Host Mouse
Isotype Mouse IgG1, κ
Isotype Control Elab Fluor® 647 Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F09792M]
Reactivity Human
Application FCM (See the Application Description)
Storage Buffer Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Recommended Use Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping Biological ice pack at 4℃
Stability & Storage Keep as concentrated solution.
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Conjugation Elab Fluor® 647
Elab Fluor® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).


How to select the appropriate detection channel through the spectrogram?

Background

CD74 is a type II transmembrane glycoprotein also known as MHC class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, and MIF receptor. CD74 exists in four isoforms with molecular masses of 33, 35, 41, and 43 kD, depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells and activated endothelial and epithelial cells as well as carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is intracellular sorting of MHC class II molecules and regulation of exogenous peptide loading onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factor) and signals through CD44 to regulate innate and adaptive immunity. It is also reported that H. pylori infection occurs through urease B binding of CD74 on gastric epithelial cells, inducing gastric epithelial cell apoptosis, NF-κB activation, and IL-8 production.

Protocols & Troubleshootings

Related Protocols Staining Cell Surface Targets for Flow Cytometry
Troubleshooting

Troubleshooting for Flow Cytometry

Alternative Formats

Product Name Sizes Price
Purified Anti-Human CD74 Antibody[LN2] 25μg, 100μg Check More
Biotin Anti-Human CD74 Antibody[LN2] 25μg, 100μg Check More
FITC Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PE Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
APC Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PE/Cyanine5 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PE/Cyanine7 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PE/Cyanine5.5 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PerCP/Cyanine5.5 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
Elab Fluor® 488 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More
PE/Elab Fluor® 594 Anti-Human CD74 Antibody[LN2] 20Tests, 100Tests, 100Tests×2 Check More

Citations

From now on, if you have published a paper by using any of our products since 1/1/2019, fill out the “Elabscience Publication Reward Application Form”carefully and send it to orders@elabscience.com, we will get back to you with the reward after we confirm it ASAP!

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