|Background||HER2 (also known as HER2 / neu, C-erbB2, erbB2 or neu) is a transmembrane receptor tyrosine kinase, which is a carcinogenic gene. Its activation will cause malignant transformation and increase the malignant potential of cells (cell proliferation, invasion, etc.). HER-2 is over expressed in 15-25% of primary breast cancer. HER-2 can also be found in gastrointestinal cancer, gastroesophageal cancer, ovarian cancer, well differentiated endometrial cancer and some salivary duct tumors. HER2-expressed breast cancer is usually associated with estrogen and progesterone receptor negative. Therefore, the poor prognosis is related to the expression of HER2.|
Immunohistochemistry of paraffinembedded Human breast cancer tissue with Her-2 Monoclonal Antibody(Antigen repaired by EDTA).