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For research use only.

Verified Samples Verified Samples in IHC: Rat heart, Mouse heart
Dilution IHC 1:50-1:200
Isotype IgG
Host Rabbit
Reactivity Mouse,  Rat
Applications IHC
Clonality Polyclonal
Immunogen Recombinant fusion protein of human MYBPC3 (NP_000247.2).
Abbre MYBPC3
Synonyms CMD1MM,  CMH4,  FHC,  LVNC10,  MYBP-C,  MYBPC3,  cardiac
Swissprot
Cellular Localization Cytoskeleton, striated muscle myosin thick filament, Cytosol, Other locations: A band, C zone, cardiac myofibril, M band, sarcomere, Z disc.
Concentration 1 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cardiovascular
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy.
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Unconjugated

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