MYLK Polyclonal Antibody (E-AB-62839)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human stomach, Rat kidney, Mouse kidney |
| Dilution | IHC 1:50-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human MYLK (NP_444253.3). |
| Abbre | MYLK |
| Synonyms | AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK, MYLK1, smMLCK |
| Swissprot | |
| Cellular Localization | Cytoskeleton, stress fiber, Cytosol, Extracellular region or secreted, extracellular exosome, Other locations: cleavage furrow, cytoplasm, lamellipodium. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. |
Other Clones
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Other Formats
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Unconjugated
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