PNKP Polyclonal Antibody

Uniprot : Q96T60
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      Catalog number:E-AB-61302

      Synonyms:2''(3'')-polynucleotidase,2'(3')-polynucleotidase,Bifunctional polynucleotide phosphatase/kinase,DEM 1,DEM1,DNA 5' kinase/3' phosphatase ,DNA 5''-kinase/3''-phosphatase,EIEE10,Homo sapiens polynucleotide kinase 3' phosphatase (PNKP),MCSZ,PNK 1,PNK1,Pnkp,PNKP DNA kinase,PNKP,Polynucleotide 3'-phosphatase,Polynucleotide 5' hydroxyl kinase,Polynucleotide 5''-hydroxyl-kinase,Polynucleotide kinase 3 prime phosphatase,Polynucleotide kinase 3' phosphatase,Polynucleotide Kinase,Polynucleotide kinase-3''-phosphatase

      Size:
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $129

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,IF

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms 2''(3'')-polynucleotidase,2'(3')-polynucleotidase,Bifunctional polynucleotide phosphatase/kinase,DEM 1,DEM1,DNA 5' kinase/3' phosphatase ,DNA 5''-kinase/3''-phosphatase,EIEE10,Homo sapiens polynucleotide kinase 3' phosphatase (PNKP),MCSZ,PNK 1,PNK1,Pnkp,PNKP DNA kinase,PNKP,Polynucleotide 3'-phosphatase,Polynucleotide 5' hydroxyl kinase,Polynucleotide 5''-hydroxyl-kinase,Polynucleotide kinase 3 prime phosphatase,Polynucleotide kinase 3' phosphatase,Polynucleotide Kinase,Polynucleotide kinase-3''-phosphatase
      Swissprot Q96T60
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human PNKP
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R217),IF
      Recommended dilution WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
      Concentration 1 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus.
      Tissue specificity Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
      Background This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.

      Images

      Western blot analysis of extracts of various cell lines with PNKP Polyclonal Antibody

      Immunohistochemistry of paraffin-embedded rat kidney with PNKP Polyclonal Antibody

      Immunohistochemistry of paraffin-embedded human lung cancer with PNKP Polyclonal Antibody

      Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cells with PNKP Polyclonal Antibody

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      MSDS for ELISA ISO 9001

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