Recombinant Cynomolgus GITR Ligand/TNFSF18 (C-6His) (PKSQ050094)
For research use only.
| Synonyms | 425O18-1, Angiopoietin-like protein 4, Angiopoietin-related protein 4, Angptl4, Farp, Fasting-induced adipose factor, Fiaf, HFARP, Hepatic fibrinogen/angiopoietin-related protein, Ng27, Secreted protein Bk89 |
| Species | Cynomolgus macaques |
| Expression Host | HEK293 Cells |
| Sequence | Glu74-Ser199 |
| Accession | A0A2K5UCD9 |
| Calculated Molecular Weight | 15.3 kDa |
| Observed Molecular Weight | 15-20 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
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