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For research use only.

Verified Samples Verified Samples in IHC: Human breast caner
Dilution IHC 1:200-1:400
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Recombinant Human ABL1 protein expressed by E.coli
Abbre ABL1
Synonyms ABL,  JTK7,  bcr/abl,  c-ABL,  c-ABL1,  p150,  v-abl
Swissprot
Cellular Localization Cytoplasm > cytoskeleton, Nucleus, Sequestered into the cytoplasm through interaction with 14-3-3 proteins and Nucleus membrane, The myristoylated c-ABL protein is reported to be nuclear.
Tissue Specificity Widely expressed
Concentration 1 mg/mL
Buffer PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4
Purification Method Antigen Affinity Purification
Research Areas Cancer,  Epigenetics and Nuclear Signaling,  Signal Transduction,  Neuroscience,  Metabolism,  Cardiovascular,  Biochemicals,  Cell Biology,  Developmental Biology,  Immunology,  Stem Cells,  Microbiology,  Tags & Cell Markers,  Isotype/Loading Controls
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity and tau phosphorylation. c-Abl has been implicated in many cellular processes including differentiation, division, adhesion, death, and stress response. c-Abl is a latent tyrosine kinase that becomes activated in response to numerous extra- and intra-cellular stimuli. The c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development and function of many mammalian organ systems, including the immune system and bone. It regulates the cellular response to TAM through functional interaction with the estrogen receptor, which suggests c-Abl as a therapeutic target and a prognostic tumor marker for breast cancer. c-Abl also plays a key role in signaling chemokine-induced T-cell migration. In addition, c-Abl contains NLSs (nuclear localization signals) and DNA-binding sequences important for nuclear functions. c-Abl has become an important therapeutic target in human chronic myeloid leukaemia.
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Unconjugated

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