Functional Antibodies

Functional antibodies are a unique class of antibodies that not only bind to specific antigens but also directly alter the function of target proteins through this binding. In contrast to conventional antibodies that are mainly used for detection and recognition, functional antibodies actively intervene in biological processes, modulating protein activity via mechanisms such as blockade, neutralization, activation, or depletion. Exhibiting exceptional value in basic research, drug development, and clinical therapeutics, these antibodies are emerging as vital research tools in the biomedical field.

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Advantages of Elabscience^® Functional Antibodies

High Purity

Purified by affinity chromatography and validated by HPLC. Purity ≥98%, monomer ratio >95%. No contaminating proteins or degraded fragments, ensuring experimental reproducibility.

Low Endotoxin

Endotoxin level ≤1 EU/mg. Contains no preservatives or carrier proteins. Suitable for both in vivo and in vitro applications.

High Compatibility

Requires no additional processing. Compatible with both in vivo animal studies and in vitro cell-based assays. Excellent batch-to-batch consistency.

Hot Targets & Custom Services

Covering popular targets in oncology, autoimmune diseases, infectious diseases, and more. Manufacturing capacity at kilogram scale. In-stock items available for immediate shipment.

Featured Functional Antibodies

Blocking Antibodies

Blocking antibodies bind to the critical functional domains of receptors or ligands, thereby blocking ligand-receptor interactions and inhibiting downstream signaling. For example, antibodies targeting immune checkpoint molecules such as PD-1 and CTLA-4 can block inhibitory signals and restore the anti-tumor activity of T cells. This class of antibodies requires precise recognition of functional epitopes—not just any epitope—demanding extremely high affinity and specificity.

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Neutralizing Antibodies

Neutralizing antibodies primarily target soluble antigens such as cytokines, toxins, or viral particles. By binding to neutralizing epitopes, they prevent the interaction between these antigens and their cell surface receptors, thereby eliminating pathogenic activity. The affinity and dissociation rate of the antibody directly influence its neutralizing potency.

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Agonistic Antibodies

Agonistic antibodies mimic the action of natural ligands by binding to receptors and activating downstream signaling pathways. For instance, certain death receptor (e.g., Fas, TRAIL-R) agonist antibodies can induce tumor cell apoptosis. The design of such antibodies must consider their ability to effectively cross-link receptors, typically requiring bivalent or multivalent binding to achieve receptor clustering.

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Cell Depletion Antibodies

Cell depletion antibodies are a class of functional antibodies that specifically target depletion-associated molecules or markers on the surface of immune cells (such as T cells, NK cells, and B cells). They can reverse or alleviate immune cell exhaustion or specifically deplete exhausted immune cells. These antibodies are primarily used in research on immune cell exhaustion mechanisms and in related diseases (such as cancer and autoimmune diseases), serving both scientific and potential therapeutic exploration.

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Elabscience^® Hot Functional Antibodies

Cat. No.	Product Name	Isotype	Clone No.
E-AB-F11320	Purified Anti-Mouse CD274/PD-L1 Antibody[10F.9G2], Functional Grade	Rat IgG2b, κ	10F.9G2
AN007850	Purified Anti-Mouse CD279 Antibody[RMP1-14], Functional Grade	Rat IgG2a, κ	RMP1-14
E-AB-F11310	Purified Anti-Mouse CD279/PD-1 Antibody[29F.1A12], Functional Grade	Rat IgG2a, κ	29F.1A12
E-AB-F11920	Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23], Functional Grade	Rat IgG2a, κ	RMT3-23
E-AB-F99980	Purified Anti-Mouse CD117 Antibody[ACK2], Functional Grade	Rat IgG2b, κ	ACK2
E-AB-F11010	Purified Anti-Mouse IFN-γ Antibody[XMG1.2], Functional Grade	Rat IgG1, κ	XMG1.2
E-AB-F12010	Purified Anti-Mouse IL-2 Antibody[JES6-5H4], Functional Grade	Rat IgG2b, κ	JES6-5H4
E-AB-F12070	Purified Anti-Mouse IL-6 Antibody[MP5-20F3], Functional Grade	Rat IgG1, κ	MP5-20F3
E-AB-F11950	Purified Anti-Human CD28 Antibody[CD28.2], Functional Grade	Mouse IgG1, κ	CD28.2
E-AB-F10010	Purified Anti-Human CD3 Antibody[OKT-3], Functional Grade	Mouse IgG2a, κ	OKT3
E-AB-F10130	Purified Anti-Mouse CD3 Antibody[17A2], Functional Grade	Rat IgG2b, κ	17A2
E-AB-F10280	Purified Anti-Mouse CD40 Antibody[FGK4.5/FGK45], Functional Grade	Rat IgG2a, κ	FGK4.5/FGK45
E-AB-F11070	Purified Anti-Mouse CD115/CSF-1R Antibody[AFS98], Functional Grade	Rat IgG2a, κ	AFS98
E-AB-F11120	Purified Anti-Mouse CD45R/B220 Antibody[RA3.3A 1/6.1], Functional Grade	Rat IgM, κ	RA3.3A 1/6.1
E-AB-F09950	Purified Anti-Mouse F4/80 Antibody[CI:A3-1], Functional Grade	Rat IgG2b, κ	CI:A3-1
E-AB-F11080	Purified Anti-Mouse Ly6G Antibody[1A8], Functional Grade	Rat IgG2a, κ	1A8