CD74 Polyclonal Antibody (AN006060L)

Name: CD74 Polyclonal Antibody
Brand: Elabscience
SKU: AN006060L
Price: 90.0 USD
Availability: InStock

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All	Size	Price	Qty
	100μL	$ 260.00	- +
	25μL	$ 90.00	- +

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Verified Samples	Verified Samples in IHC: Human tonsil, Human lung cancer, Human breast cancer
Dilution	IHC 1:50-1:100
Isotype	IgG
Host	Rabbit
Reactivity	Human
Applications	IHC
Clonality	Polyclonal
Immunogen	Recombinant Human CD74 protein expressed by E.coli
Abbre	CD74
Synonyms	CD74 antigen (invariant polypeptide of major histocompatibility complex, classII antigen-associated), CD74 antigen, CD74 molecule, major histocompatibility complex, class II invariant chain, CD74, CLIP, DHLAG, DHLAGgamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLADG, HLA-DR antigens-associated invariant chain, HLA-DR-gamma, Ia antigen-associated invariant chain, Ia-associated invariant chain, Ia-gamma, Ii, INVG34, MHC HLA-DR gamma chain, p33
Swissprot	P04233
Cellular Localization	Cell membrane, Endosome, Lysosome, Secreted
Tissue Specificity	Detected in urine (at protein level).
Concentration	1 mg/mL
Buffer	PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
Purification Method	Antigen Affinity Purification
Research Areas	Immunology
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
background	Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.