Frataxin/FXN Polyclonal Antibody (AN000510P)
For research use only.
| Verified Samples | Verified Samples in ELISA: Recombinant Human FRataxin/FXN protein, Human serum, Human plasma |
| Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | ELISA Capture/Detector |
| Clonality | Polyclonal |
| Immunogen | Recombinant Human Frataxin/FXN protein expressed by E.coli |
| Abbre | Frataxin/FXN |
| Synonyms | CyaY, d-FXN, FA, FARR, Frataxin mature form, Frataxin(81-210), FRDA, FRDA, Friedreich ataxia protein, Fxn, i-FXN, m56-FXN, m78-FXN, m81-FXN, MGC57199, X25 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer, Metabolism, Signal Transduction, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | FXN,also named as FRDA,X25,m81-FXN,d-FXN,m78-FXN and i-FXN,belongs to the frataxin family. It promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. FXN may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. FXN is cleaved to be 4 chains. FXN is expressed in the cytoplasm as a 210 amino acid (AA) precursor protein (pFXN; 23 KDa) that is translocated into mitochondria where it is processed by two consecutive steps into iFXN (FXN 42-210; 19 KDa) and finally mFXN (81-210; 14.2 KDa),which is functional. |
Other Clones
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Unconjugated
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