Human CASP3 Antibody Pair Set (E-KAB-0496)
For research use only.
| Background |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease ( caspase ) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits , large and small , that dimerize to form the active enzyme. This protein cleaves and activates caspases 6 , 7 and 9 , and the protein itself is processed by caspases 8 , 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein , which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
|
| Synonyms |
CPP32, CPP32B, SCA-1, Apoptain, Yama
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human CASP3 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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