ICAM-1/CD54 Monoclonal Antibody(Capture) (AN001650P)
For research use only.
| Verified Samples | Verified Samples in ELISA: Recombinant Human ICAM-1/CD54 protein, Human serum, Human plasma |
| Dilution | ELISA Capture 2-8 μg/mL |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | ELISA Capture |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human ICAM-1/CD54 protein expressed by Mammalian |
| Abbre | ICAM-1/CD54 |
| Synonyms | Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1 |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Immunology, Cardiovascular, Stem Cells |
| Clone No. | 4C3 |
| Conjugation | Unconjugated |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended. |
| background | Intercellular adhesion molecule-1 (ICAM-1,or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells,but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally,ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated,leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics,ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE),providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
Other Clones
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Unconjugated
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