Recombinant Human Cathepsin S/CTSS Protein (His Tag) (PKSH033736)

For research use only.
Synonyms | CTSS, Cathepsin S, MGC3886 |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | Gln17-Ile331 |
Accession | AAH02642.1 |
Calculated Molecular Weight | 36.9&25&11.2 kDa |
Observed Molecular Weight | 37-40&26-28&14-16 kDa |
Tag | C-His |
Bio-activity | Not validated for activity |
Purity | > 90 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 10% Glycerol, pH 5.5. |
Reconstitution | Not Applicable |
Background | Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. This protein is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia. Moreover, cathepsin S is expressed in some epithelial cells. Compared with the abundant cathepsins B, LandH, cathepsin S shows a restricted tissue distribution, with highest levels in spleen, heart, and lung. In addition, evidences indicated that cathepsin S generates A beta from amyloidogenic fragments of beta APP in the endosomal/lysosomal compartment, and is implicated in the pathogenesis of Alzheimer’s disease(AD) and Down Syndrome (DS). |
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