Recombinant NPC2 Monoclonal Antibody (AN300055P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human epididymis |
| Dilution | IHC-P 1:100-1:500, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Rabbit Monoclonal |
| Immunogen | Recombinant Human NPC2 Protein |
| Abbre | NPC2 |
| Synonyms | NPC, HE1, NPC2, EDDM1, Epididymal protein 1, Epididymal secretory protein, Epididymal secretory protein E1, Human epididymis-specific protein 1, Niemann-Pick disease type C2, Niemann-Pick disease type C2 protein, NPC intracellular cholesterol transporter 2, Tissue specific secretory protein |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cardiovascular, Signal Transduction, Neuroscience, Metabolism |
| Clone No. | 6G9 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation. |
Other Clones
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Unconjugated
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