Recombinant TROP-2/TACSTD2 Monoclonal Antibody (AN300565P)
For research use only.
| Verified Samples | Verified Samples in IHC: Mouse skin, Mouse kidney |
| Dilution | IHC-P 1:10000-1:20000 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse TROP-2/TACSTD2 protein |
| Abbre | TACSTD2 |
| Synonyms | EGP, Cell surface glycoprotein Trop, Tumor-associated calcium signal transducer, GA733, TACSTD, C80403, Cell surface glycoprotein Trop-2, EGP-1, GA733-1, Ly97, TROP-2, Tumor-associated calcium signal transducer 2, Trop2, Tacstd2 |
| Swissprot | |
| Tissue Specificity | Expressed in kidney, lung, ovary and testis. High levels of expression in immortalized keratinocytes. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | B495 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
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Unconjugated
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