Recombinant VE-Cadherin/CD144/CDH5 Monoclonal Antibody (AN300186P)
For research use only.
| Verified Samples |
Verified Samples in IF: HUVEC Verified Samples in FCM: HUVEC |
| Dilution | ICC/IF 1:20-1:100, FCM 1:25-1:100, |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | FCM, ICC/IF |
| Clonality | Rabbit Monoclonal |
| Immunogen | Recombinant Human VE-Cadherin / CD144 / CDH5 Protein |
| Abbre | CDH5 |
| Synonyms | CDH, Cadherin 5 Type, cadherin, CDH5, 7B4, CD144, cadherin-5, Cadherin 5 Type 2, VE-Cadherin, Cadherin-5, 7B 4, 7B4 antigen, CADH5, Cadherin 5, Cadherin5, CD 144, CD144 antigen, CDH 5, CDH5 protein, Endothelial specific cadherin, FLJ17376, OTTHUMP00000174777, type 2, type 2 (vascular endothelium), vascular endothelial, Vascular endothelial cadherin, Vascular epithelium cadherin, VE Cad, VE cadherin (vascular epithelium), VEC |
| Swissprot | |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Cancer, Cardiovascular, Tags & Cell Markers |
| Clone No. | 5C3 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis. |
Other Clones
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Other Formats
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Unconjugated
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