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For research use only.
| Verified Samples |
Verified Samples in IHC: Mouse kidney, Mouse brain Verified Samples in IF: C6, NIH/3T3, U-2OS |
| Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human SET (NP_003002.2). |
| Synonyms | 2PP2A, I2PP2A, IGAAD, IPP2A2, PHAPII, SET, TAF-I, TAF-IBETA |
| Swissprot | |
| Cellular Localization | Cytoplasm, cytosol, Endoplasmic reticulum, Nucleus, nucleoplasm, In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum, Following CTL attack, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus, Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium, The SET complex is associated with the endoplasmic reticulum. |
| Concentration | 1 mg/mL |
| Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. |
Other Clones
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